Carl Sagan on History of science

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The history of science—especially physics—has in part been the tension between the natural tendency to project our everyday experience on the universe and the universe's noncompliance...
Carl Sagan
Humans may crave absolute certainty; they may aspire to it; they may pretend, as partisans of certain religions do, to have attained it. But the history of science — by far the most successful claim to knowledge accessible to humans — teaches that the most we can hope for is successive improvement in our understanding, learning from our mistakes, an asymptotic approach to the Universe, but with the proviso that absolute certainty will always elude us.
Carl Sagan