[T]he veterinary deworming drug ivermectin has become the new hydroxychloroquine in that it is being promoted as a highly effective treatment against COVID-19—and by many of the same people... despite evidence that is, at best very weak and at worst completely negative. Unfortunately, with the publication of two new and biased reviews, the "HCQ vibe" about ivermectin is stronger than ever. ...I concede that it is possible that ivermectin has clinically relevant in vivo antiviral activity against SARS-CoV-2. Based on current evidence, however, it seems unlikely that it does, when pharmacokinetics considerations are taken into account. As I routinely used to say when discussing hydroxychloroquine, I’d be happy to change my mind if compelling scientific evidence for ivermectin were published. It’s just that neither of these reviews qualify, nor do any of the clinical trials I’ve seen thus far. That’s why I agree that ivermectin shouldn’t be used to treat COVID-19 outside of the context of a well-designed clinical trial with a strong scientific rationale. Certainly, the conspiracy mongering by Bret Weinstein, Pierre Kory, and their fans are not leading me to reconsider that opinion.

What It Means

This is a placeholder explanation generated by the low-overhead model. It interprets "[T]he veterinary deworming drug ivermectin has become the new hydroxychloroquine in that it is being promoted as a highly effective treatment against COVID-19—and by many of the same people... despite evidence that is, at best very weak and at worst completely negative. Unfortunately, with the publication of two new and biased reviews, the "HCQ vibe" about ivermectin is stronger than ever. ...I concede that it is possible that ivermectin has clinically relevant in vivo antiviral activity against SARS-CoV-2. Based on current evidence, however, it seems unlikely that it does, when pharmacokinetics considerations are taken into account. As I routinely used to say when discussing hydroxychloroquine, I’d be happy to change my mind if compelling scientific evidence for ivermectin were published. It’s just that neither of these reviews qualify, nor do any of the clinical trials I’ve seen thus far. That’s why I agree that ivermectin shouldn’t be used to treat COVID-19 outside of the context of a well-designed clinical trial with a strong scientific rationale. Certainly, the conspiracy mongering by Bret Weinstein, Pierre Kory, and their fans are not leading me to reconsider that opinion." in the context of "David Gorski, "Ivermectin is the new hydroxychloroquine, take 2" (June 21, 2021) Science Based Medicine." to mean that wisdom is timeless.